Organ donation is the process of surgically removing an organ or tissue from one person (the organ donor) and placing it into another person (the recipient). How the Donation Process Works. Transplantation is necessary because the recipient’s organ has failed or has been damaged by disease or injury. The “waitlist” is a list of candidates registered to receive organ transplants. The organ donation process may involve the recovery of lungs, kidneys, heart, liver, pancreas and intestines for transplantation to severely ill patients on the organ transplant waiting list.. Tissue donation may include corneas, bone, skin, heart valves, nerves, blood vessels, ligaments, tendons and other soft tissue. Traditional organ donation requires a person to be in a hospital and on a ventilator when they are pronounced brain dead. OPOs are on the front-line of organ procurement, and work directly with a decedent’s family during the emotional discussion about the potential donation of the gift of life. Many factors used to match organs with patients in need are the same for all organs, but the system must accommodate some unique differences for each organ. CORE coordinates the recovery of organs, tissues and corneas for transplant. If a person experiences cardiac death, which means the heart has stopped and will not work again, they will be evaluated for tissue and cornea donation.